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The risk of bias in the included casecontrol study was assessed using Newcastle-Ottawa Quality Assessment Form for casecontrol studies

After treatment withdrawal, body weight regain was observed in both the semaglutide and placebo arms (Figure 1A and Tables 2 and S1)

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For instance, liraglutide improved ED by regulating smooth muscle dysfunction and oxidative stress in a GLP-1 receptor-dependent fashion in a rat model of type 1 diabetes 99

Research suggests semaglutide may provide cardiovascular benefits beyond weight loss alone