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These projections from the area postrema to the RVLM may constitute potential pathways activated by GLP-1 to elicit sympathetic responses
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Glucagon-like peptide-1 (GLP-1) is a naturally occurring incretin hormone produced primarily by specialised L-cells in the distal small intestine and colon
Elevated intracellular cGMP levels activate protein kinase G type 1 (PKG-1), which lowers cytosolic calcium concentrations and activates calcium-dependent potassium (KCa) channels, favoring VSMC hyperpolarization and smooth muscle relaxation [22,23]
