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Acting on the cardiovascular system GLP-1 may have certain effects on the cardiovascular system, mainly manifested as increased heart rate and changes in blood pressure.Heart rate increase: The use of GLP-1 receptor agonists can cause an increase in heart rate in patients, and the magnitude of the increase in heart rate is related to the duration of GLP-1 action

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In humans, GIP may inhibit bone resorption during intravenous infusion, and the antiresorptive effect appears to be more pronounced during hyperglycemia ( In vitro studies suggest that GLP-1 may promote bone formation in humans by affecting osteogenic progenitor cell differentiation, but there is a lack of similar studies on the effects of GLP-1 and GLP-1RAs on mature osteoblasts

Numerous challenges had to be addressed through peptide engineering and pharmacokinetic-pharmacodynamic (PK-PD) modelling to develop MEDI4166

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