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Important safety considerations include the risk of hypoglycemia when tirzepatide is used in combination with insulin or sulfonylureas (requiring dose adjustments of these medications), potential thyroid C-cell tumor risk (contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2), and the possibility of acute pancreatitis

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Include resistance training two to three times per week to preserve muscle during weight loss with tirzepatide dosing for weight loss in units