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Effects of GLP-1 receptor agonists on bone health in preclinical models The first indications of a GLP-1 effect on the skeleton were derived from phenotype assessments of GLP-1R knockout (KO) mice

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Type 2 diabetes mellitus was effectively prevented by administering ALO to diabetic rats in vivo [179]

Another review comparing the two drugs shows 11% loss of body weight for tirzepatide and 7% with semaglutide over 36 weeks

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