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Description
Within the tirzepatide treatment arm, the studys most common adverse effect, gastrointestinal disorders, occurred in 46.0% of patients who experienced a cardiorenal end point versus 41.4% of patients who did not
Finally, patients on GLP-1 RAs undergoing elective surgical procedures may need the therapy held before surgery [61]

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Development Speed and Consistency: Chemical synthesis is generally and highly reproducible, faster for straightforward, short peptides

Immunology Today

They started making synthetic analogs, lab-built versions that work like GLP-1 but dont break down so fast
