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Although tachyphylaxis to this effect may occur with long-acting GLP-1 receptor agonists, GLP-1-associated slowing of gastric emptying does not appear to be responsible for the nausea and vomiting often reported with the use of GLP-1 receptor agonist treatment

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Glucagon-like peptide-1 (GLP-1): Effect on kidney hemodynamics and renin-angiotensin-aldosterone system in healthy men

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In this context, GLP-1 RAs may offer a practical advantage: Patients with obesity may be more motivated to adhere to a therapy that also promotes weight loss and improves metabolic health, compared with adding a fourth or fifth antihypertensive agent

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