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Mitsubishi, Tokyo, Japan

NAMPT, nicotinamide phosphoribosyltransferase (Adapted from Cant et al., Curr Opin Lipidol 2009;20:98-105 [29])

GLP-1 decreases gastric emptying, inhibits food intake, increases natriuresis and diuresis, modulates rodent -cell proliferation, regulates the hypothalamic-pituitary-adrenal (HPA) axis in rats, and has cardio- lung- and neuroprotective effects [25,26,27,28,29,30,31]

This selection is further supported by the CV outcomes data for specific GLP-1RAs, which point to benefits in reducing the risk of MACE in at-risk individuals [16,17,18]

Investment analysts expect production costs of orforglipron to be 30 to 50% lower than injectables