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Using an integrated ligand and structure-based virtual screening pipeline, explicitly combining complementary ligand-based descriptors, multi-fingerprint similarity, electrostatic similarity, pharmacophore modeling, and multi-conformation docking under a consensus-driven selection strategy, we were able to identify three chemically distinct classes of GLP-1R agonist candidates: GQB47810, a non-peptidic molecule

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In 5 years, obesity drugs went from 15% weight loss (Wegovy) to 29% (Retatrutide)

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GLP-1s were created to help treat type 2 diabetes, but now they have shown real promise in helping people lose weight