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While the medications themselves do not appear to cause blood clots, certain patient characteristics significantly elevate baseline thrombotic risk

The most common effects include nausea, reduced appetite, bloating, constipation, diarrhea, or fatigue during the first few weeks

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This combination therapy may optimize disease management, particularly in patients with severe, refractory HS or those with significant metabolic comorbidities

The roughly six-day half-life means levels stay relatively steady between doses, avoiding the sharp swings that can make some compounds feel uneven