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On its own its effects are modest, but combined with GLP-1 the two create a synergistic effect that amplifies both glycemic control and fat reduction beyond what either achieves alone which is why tirzepatide generally outperforms semaglutide in head-to-head comparisons

Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide

Fundamentally, GLP-1RAs work by stimulating insulin secretion and inhibiting glucagon secretion in a glucose-dependent manner [9], which explains their associated low risk of hypoglycaemia

Phosphorylation of channel components by PKA is likely responsible for modulating pore activity [49,82,83]

These agents include: Liraglutide (Victoza, Saxenda) once-daily injection Semaglutide (Ozempic, Wegovy) once-weekly Tirzepatide (Mounjaro) a dual GLP-1/GIP agonist From Glycaemic Control to Weight Regulation GLP-1RAs were initially licensed to lower HbA1c in people with Type 2 diabetes, offering an alternative to sulfonylureas and insulin