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Tirzepatide (MD: 10 kg, 95%CI: 12, 8.2), semaglutide (MD: 3.8 kg, 95%CI: 4.9, 2.7), EBID (MD: 2.8 kg, 95%CI: 4.2, 1.4), liraglutide (MD: 2.1 kg, 95%CI: 3.2, 1.1), lixisenatide (MD: 2.0 kg, 95%CI: 3.3, 0.75) and dulaglutide (MD: 1.2 kg, 95%CI: 2.1, 0.25) showed statistically significant reduction in weight from baseline in comparison to traditional antidiabetic drugs (S8 Fig)

Acute kidney injury has been reported, typically in the context of severe dehydration from gastrointestinal side effects

The CDSCO has just issued a clear advisory (dated March 11, 2026) directing all manufacturers, importers, and marketing authorization holders of GLP-1 receptor agonists (like semaglutide/Ozempic, tirzepatide/Mounjaro, etc.) to strictly avoid any promotional activities for these prescription-only drugs used in obesity management

Wegovy contains a higher dose of semaglutide and is specifically FDA-approved for chronic weight in adults who are overweight

Compounded GLP-1/GIP is listed at $179 per month

A study published in the Journal of Medical Toxicology by researchers at the University of Alabama at Birmingham found that reports of overdoses of popular injectable weight-loss medications to a regional poison control center have increased substantially over the last few years