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However, many people obtain these drugs online or through private channels, creating risks of scams and incorrect use

Regarding BMI, our results showed that GLP-1 agonists had a progressive impact on BMI reduction over time, with statistically significant effects emerging at 6 months and persisting up to 24 months, at 3 months, the mean difference (MD) was 0.36 (95% CI: 1.22, 0.50) with 0.0% heterogeneity ( I 2 ) and a p -value of 0.4102

They consequently improve postprandial hyperglycemia

Interestingly, tirzepatide, a dual-acting GIP/GLP-1 receptor agonist that is now clinically approved for both obesity and T2D, was designed with an amino acid sequence closely resembling that of native GIP, resulting in strong preference for GIPR binding over the GLP-1R

Therefore, focusing exclusively on BMI may delay preventive intervention

Fu J, Nchambi KM, Wu H, Luo X, An X, Liu D