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Thus, oral administration of a peptide therapeutic represents a significant advance in medicine, but is challenged by gastrointestinal instability and ineffective uptake into the circulation

Until recently, therapeutic strategies remained limited to lifestyle interventions, with few pharmacological options demonstrating meaningful clinical benefit

PMCID: PMC9709280
**Functional Screening:** * The 10,000 designed GLP-1RAs underwent virtual screening based on stability, efficacy, and diversity criteria, which narrowed down the candidates to 60
