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BrightFocus Alzheimers Disease Research program has funded research into brain metabolism, inflammation, and novel therapeutic approaches that helped lay the groundwork for innovative discoveries like GLP-1s in Alzheimers disease
They diagnosed males 1.4 times more often than females
9 Distinguishing failed biology from failed pharmacology: a decision framework A central objective of this review is to distinguish peptidereceptor systems that were abandoned due to intrinsic biological limitations from those that failed primarily because of incomplete pharmacologic execution

More encouragingly, a phase II randomized controlled trial (RCT) of lixisenatide ( n = 156) reported slower motor decline over 12 months (159), while liraglutide improved nonmotor symptoms but not motor endpoints (160)

The problem is that pricing pressures and patent expirations are expected to be significant headwinds for Novo Nordisk in the near term
