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& Voigt, N

What Clinical Trials Show In large obesity trials: Average weight loss is ~15% of starting body weight with semaglutide 2.4 mg Average weight loss is ~2022% of starting body weight with tirzepatide 15 mg The majority of weight loss occurs within the first year of treatment Plateaus are common after significant weight reduction Some people lose more, some less but a flattening of the weight-loss curve is expected , especially after meaningful progress has already occurred

But it's still in early research and hasn't yet been tested in humans

Research shows a calorie deficit of 500-750 kcal/day will help you lose weight gradually

Body weight loss was also observed

Appetite suppression can lead people to eat very little, which worsens side effects