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[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Aroda VR, Saugstrup T, Buse JB, Donsmark M, Zacho J, Davies MJ

Additionally, certain medications, birth control changes, or even sudden lifestyle shifts may play a role

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Mental stress should be addressed among individuals with obesity, as chronic stress may promote obesity development through the sympathetic nervous system and hypothalamic-pituitary-adrenal axis activation that elevates cortisol levels, interferes with insulin sensitivity, promotes energy storage, and creates food cravings for ultra-processed comfort foods [180] GLP-1s may act both centrally and peripherally to reduce these downstream impacts of chronic stress and obesity and alter food reward pathways in positive ways [124]