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How does sustained use affect bone mineral density and lean mass over years rather than months

When patients are placed on the same extreme low-calorie diet and then randomized to receive HCG or placebo , both groups lose a comparable amount of weight

Orforglipron treatment also improved several cardiometabolic measures, including waist circumference, systolic blood pressure, and fasting lipid levels

Patients were dosed for 12 weeks and subsequently discontinued for 4 weeks
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