does glp 1 only work by suppressing appetite semaglutide do anything other than suppress Most weight loss medications through a single What Is GLP-1 and Why

It is well established that patients with diabetes demonstrate higher susceptibility to pancreatic cancer and pancreatitis compared to non-diabetic individuals, and theoretically, sustained GLP-1 receptor activation induced by GLP-1RA therapy may potentially elevate pancreatic cancer risk [8]

Dietary restrictions combined with appetite suppression could push caloric intake dangerously low

GLP-1 specifically binds to the glucagon-like peptide-1 receptor (GLP-1R) in the body, directly stimulating the secretion of insulin by pancreatic -cells, promoting proliferation and differentiation, and inhibiting cell apoptosis, thereby exerting a glycemic lowering effect

doi:10.3390/nu16172886

Liu, C., Zhang, Q., Zhou, H., Jin, L., Liu, C., Yang, M., Zhao, X., Ding, W., Xie, W., & Kong, H

25 In the early 1990s, despite John Engs team identifying a potential diabetes treatment in exendin-4, it initially lacked attention and funding for development