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Pharmacologic therapy should be guided by person-centered treatment factors, including comorbidities, considerations of adverse effects (including hypoglycemia), treatment burden, and treatment goals and preferences

Physical stresses include exposing the body to injury, walking outside in cold and wet conditions without a coat on, or malnutrition

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So really it's not costing the system anything

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Before injecting, the pen can be left at room temperature for a few minutes to reduce discomfort during injection
