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Patients with significant hepatic steatosis: Early data suggests retatrutide's glucagon component may outperform tirzepatide specifically on liver fat reduction (NAFLD/MASLD endpoints)

These results are comparable to surgical interventions learn more about how Retatrutide compares to bariatric surgery in our detailed analysis

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Others prefer injecting 2-3 days before their rest day, so the peak suppressive window falls on rest days when caloric demand is lower anyway

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Clinical trials demonstrate that semaglutide can produce approximately 15% body weight reduction over 68 weeks, while tirzepatide can achieve about 21% reduction over 72 weeks when combined with lifestyle modifications in people without diabetes