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The first demonstration that DPP-4 inhibition reduces blood glucose levels in type 2 diabetes was published in 2002 [36]

Anyone experiencing any vision changes should contact their doctor immediately. Manjot K

A popular dual agonist, tirzepatide (Mounjaro), activates both GLP-1R and GIPR, producing synergistic effects on insulin secretion, appetite suppression, and weight reduction (Table 1)

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The use of GLP-1RA and Contrave involves escalating dose protocols, as illustrated in the attached images

doi: 10.1016/j.ejphar.2021.174310 [DOI] [PubMed] [Google Scholar] 47
