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A more recent study that used the SELECT trial participants to examine the effect of semaglutide weight and anthropometric measures, showed that semgalutide demonstrated a significant mean weight reduction of 10.2% at week 208 compared to only 1.5% of the placebo group, sustained over 4 year 32

GLP-1 Agonists Medication injections may be the answer

Thyroid C-Cell Tumors: In mice and rats, semaglutide (the active ingredient in Wegovy, Ozempic, and Rybelsus) caused an increase in thyroid C-cell tumors, including medullary thyroid carcinoma (MTC)

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Several clinical scenarios warrant discussion: You should consider speaking with your GP if: You have type 2 diabetes that is inadequately controlled despite lifestyle modifications and metformin therapy, and your HbA1c remains above target You are struggling with weight management despite optimised thyroid hormone replacement, and you might meet NICE criteria for medical weight management (typically requiring referral to specialist weight management services) You have cardiovascular disease alongside type 2 diabetes, as some GLP-1 agonists (semaglutide, liraglutide, dulaglutide) have demonstrated cardiovascular benefits Your current diabetes medications are causing problematic side effects or hypoglycaemia Before your appointment , it is helpful to: Ensure your thyroid function has been checked recently (within the past 6 months) Compile a list of all current medications, including levothyroxine dose and timing Document your weight history and any previous weight management attempts Note any family history of thyroid cancer or endocrine conditions Prepare questions about potential benefits, risks, and alternatives Your GP will assess your suitability for GLP-1 therapy by reviewing your medical history, current thyroid status, diabetes control (if applicable), and overall health

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