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doi: 10.1056/NEJMoa1411892 21 RubinoDMGreenwayFLKhalidUO'NeilPMRosenstockJSrrigRet al

"People can lose more fat." Retatrutide: Next-gen obesity drug helps patients lose 28% of body weight In a phase-three trial by Eli Lilly, patients on the highest dose lost an average of 28.3% of their body weight over a year and a half, and more than 45% of participants lost at least 30%, a level of efficacy the company said approaches results seen with bariatric surgery

Those findings were published in However, other studies have provided conflicting evidence

As the dosage gradually increases, appetite suppression becomes more noticeable, typically between weeks 4 and 8