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This resulted in the first generation of GLP-1 receptor agonists, including exenatide and lixisenatide

Gastroenterology 150(5):11471159 e1145

In fasted rats, co-administration of GLP-1 and GLP-2 leads to a greater inhibition of small bowel motility relative to either monotherapy [793]

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This process entails the adhesion of the peripheral immune cells to endothelial cells, which facilitates their translocation across the blood-brain barrier, ultimately resulting in barrier disruption, cerebral edema, and brain injury, which indirectly promote the infiltration of peripheral immune cells (69)

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