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J Biol Chem (2013) 288:3558191

In those with T2DM who continue to have an A1C above target despite dual/triple therapy with metformin and other antidiabetic agents, the GLP-1 receptor agonists and dual agonists are preferred injectable medications to insulin due to similar or even better efficacy in A1C reduction, lower risk of hypoglycemia, and cardiovascular and renal protective benefits

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