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[4] "Instead of just saying young women suffer from IBS, we wanted rigorous science explaining why." Holly Ingraham, PhD, Herzstein Professor of Molecular and Cellular Pharmacology, UCSF "We knew the gut has a sophisticated pain-sensing system, but this study reveals how hormones can dial that sensitivity up by tapping into this system through an interesting and potent cellular connection." David Julius, PhD, Nobel Laureate in Physiology or Medicine, UCSF Earlier foundational work, published in PubMed, confirmed that variations in ovarian hormones across the menstrual cycle affect sensorimotor GI function