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GLP-1 biosimilars are follow-on biologic or peptide therapeutics developed to demonstrate high similarity to approved GLP-1 receptor agonist drugs

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CGM (N=101) + GLP-1 vs GLP-1 only (N=5840)

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For example, while ip injection of the GHSR antagonist JMV2959 alone has no impact on CFA [132], infusion of ghrelin directly in the lateral amygdala prevents the acquisition of a lithium chloride-induced CFA in a GHSR-dependent manner [133,134] but also its extinction [135]