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Metformin has a known GI effect that tends toward looser stools in some patients, which can partially offset GLP-1-related constipation

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Collectively, these findings revealed the essential physiological actions of GLP-1R and GIPR signaling for islet hormone secretion in mice and humans (5)

Clinical Rationale for Early AOM Intervention Traditional obesity management often follows a fixed-duration behavioral therapy (BT) approach before considering medication, yet mounting evidence suggests this may not be optimal for many patients

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