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( 10.2337/dc12-2713) [DOI] [PMC free article] [PubMed] [Google Scholar] 10.Waser B, Blank A, Karamitopoulou E, et al

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The clinical value lies in metabolic protection during weight loss: sermorelin offsets the lean muscle loss and metabolic slowdown that typically accompany caloric restriction, while semaglutide handles appetite suppression and glycemic control

The high degree of TH/GLP-1R overlap in the AP, together with the presence of semaglutide in these neurons (Figure 5), suggests a direct action of the 2 GLP-1RAs on GLP-1R/TH neurons in the AP