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Participants were randomly assigned in a 1:1 ratio to receive either semaglutide 50 mg or a placebo once daily for 68 weeks
As researcher Anton Pottegard explained to Medscape Medical News, 'This makes the results quite valuable, as they provide reassurance that the recent concern does not seem to be supported by data'
73 A post hoc analysis suggested that a higher proportion of insulin-resistant patients in the phase 2 trial may have contributed to the discrepant results, because Exenatide PD3 showed a non-significant trend toward benefit only in the small insulin-resistant subgroup

6 Whether this signal extends to patients who have already experienced an overdose, regardless of their original indication for GLP-1 therapy, has not been established
Hypertension (Dallas, Tex: 1979)
Its starting dose is typically 1.5 milligrams (mg) and goes up to 25 mg, according to a press release from Novo Nordisk, the manufacturer of the drug