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GLP-1 medications, such as Ozempic , mimic these natural effects to help with weight loss and blood sugar control

However, many Type 2 diabetics will not achieve sufficient control of their blood sugar on metformin alone and will be placed on one or more additional therapies, as outlined in the previously mentioned treatment guidelines

Its most critical role during GLP-1 therapy is helping to preserve lean muscle mass

Activation of FXR by the gut microbiota was shown to reduce the expression levels of most bile acid synthesis enzymes and inhibit the expression of gluconeogenic genes (201, 202), thereby linking the intestinal microbiota to the regulation of bile acids and metabolic homeostasis

Shimokawa, C

In laboratory preclinical studies, these drugs help reduce harmful protein clumps in the brain