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The Ala substitution at E364 6.53b caused a 58-fold reduction in affinity with a 15-fold reduced potency (Coopman et al., 2011), whereas the individual substitutions of E364 6.53b with Tyr, Asp, or Gln did not affect GLP-1 affinity or potency (Yang et al., 2016)

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The functional significance of p53 is underscored by somatic mutations that deactivate p53 in up to 50% of human cancers

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