reviews of patched glp-1 Do Patches Work for Weight Loss or Curbing Appetite? Do GLP-1 Patches Work​?

SOURCE: Nature Medicine , Jan

J Physiol 587:2732 Hansen L, Deacon CF, Orskov C, Holst JJ (1999) Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine

As with GLP-1 prior to the advent of long-acting analogs, incomplete translational tools may explain the gap between strong preclinical biology and equivocal human data

Replacement of N240 3.43b with Ala in rat GLP-1R reduced affinity by more than 20-fold and severely impeded cAMP production induced by 100 nM GLP-1 (Xiao et al., 2000), whereas the equivalent replacement in hGLP-1R had minimal effects on affinity but reduced E max of GLP-1 to 78% (Log c = 0.67

[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Taylor V., MacQueen G

It does not require refrigeration, making it more convenient for travel and storage than many injectables