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166,167 By reducing inflammation, GLP-1 RAs help mitigate the chronic inflammation associated with aging, promoting healthier aging and lowering the risk of diseases such as CVDs and NDs

It mimics the action of GLP-1 hormone to suppress appetite and maintain blood sugar levels

If glycemic targets are not achieved with insulin, consider GLP1-RA or SGLT2i or DPP4i as add-on therapy

Recent negative outcomes from the pivotal phase 3 EVOKE and EVOKE+ trials, which demonstrated no clinical benefit of oral semaglutide in patients with early AD, have resulted in a notable translational paradox

[DOI] [PubMed] [Google Scholar] 5.Sikirica M

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