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Conversely, cerebral insulin resistance leads to increased body weight and obesity

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In addition, the sponsor of the drug was contacted for information regarding unpublished studies

In line with this, some research suggests that antagonism of GIP receptors is beneficial for decreased weight gain 147,148 and that CNS GIPR knockout mice are protected from diet-induced obesity 149

While some patients would prefer a low-dose SSRI, others will need a higher dose and possibly extra medication management

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