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In recent years, the mechanism of action and therapeutic applications of GLP-1R have received extensive attention, especially in the field of diabetes and obesity treatment (Zheng et al., 2024)

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GLP-1R activation in the hippocampus has been associated with neuroprotective effects and modulation of cognitive functions, which may indirectly affect reward-related behaviors [29]

Characterization of allosteric peptide-modified liposomes and their penetration of the blood-brain barrier The mean diameter and -potential of the PEGylated ITP-modified liposome (PEG-ITP-Lip) were 87.40 9.81 nm and 24.57 1.60 mV, respectively (Fig

There may be direct pharmacological effects through central GLP-1 pathways, as well as indirect consequences of the medication's intended actions and associated side effects