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Although proposed mechanismssuch as modulation of the HPA axis and central GLP1 receptor signallingsuggest potential antidepressant effects, clinical findings remain inconsistent

It also discusses key challenges in their development and explores future directions, including clinical considerations and emerging research with triple agonists

Efficacy and safety of liraglutide added to insulin treatment in type 1 diabetes: the adjunct one treat-to-target randomized trial

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Cumulative 36-month NAION incidence hit 8.9% in the diabetic semaglutide cohort versus 1.8% in comparators