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Keywords: Glucagon-like peptide-1 receptor agonists, GLP-1-RAs, Precision medicine, Cancer risk Introduction Amid the continuously increasing global incidence of diabetes, glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as a cornerstone in type 2 diabetes treatment, demonstrating remarkable efficacy in glycemic control and cardiovascular risk reduction [1, 2]

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( 3.3 Development of unimolecular agents targeting both GIPR and GLP-1R The anti-obesity effects of GIPR antagonism antibody, both alone and in combination with GLP-1RAs, have been demonstrated in preclinical models of mice and monkeys (68, 73)

In ovariectomized rats, subcutaneous replacement of estradiol potentiates suppression of total food intake induced by CCK (22, 131, 132)

Time-lagged bolus injection of LINA after EMPA significantly increases USE in SD rats To study acute effects of LINA on USE under the presence or absence of SGLT2is, we performed acute injection experiments with EMPA alone, LINA alone, concurrent administration with EMPA and LINA, and time-lagged bolus injection of LINA an hour after EMPA into the SD rats

In a recent study published in the eClinicalMedicine , a group of researchers evaluated the association between Glucagon-like peptide-1 receptor agonists (GLP-1 RA) use and the risk of suicide or suicide attempt, accounting for psychiatric history and obesity