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If left untreated, it often advances to non-alcoholic steatohepatitis, marked by inflammatory and/or fibrotic hepatic changes, leading to the eventual development of non-alcoholic fatty liver disease-related cirrhosis and hepatocellular carcinoma

NA, Synonyms: , Chemical name: (3S,9S,12S,15S,18S,21S,24S,27S,30S,36S,39S,42S,45S,48S,51S,54S,81R)-54-(((S)-1-(((S)-1-(((S)-1-(((S)-4-amino-1-carboxy-4-oxobutyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-3-(2-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-2-methylpropanamido)-51-(3-amino-3-oxopropyl)-42-(4-aminobutyl)-12-benzyl-30,45-di((S)-sec-butyl)-21,39-bis(carboxymethyl)-24-(4-hydroxybenzyl)-9,15-bis((R)-1-hydroxyethyl)-18,27-bis(hydroxymethyl)-36-isobutyl-33,33,48-trimethyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,60,69,78,83-henicosaoxo-62,65,71,74-tetraoxa-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,59,68,77,82-henicosaazahenhectane-1,81,101-tricarboxylic acid

Some reviews show a neutral effect on resting energy expenditure, and GLP-1 therapies can even reduce sleeping energy expenditure through adaptive thermogenesis after weight loss

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