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What the 2025 Gastroenterology Metaanalysis Found The systematic review and metaanalysis (DOI: 10.1053/j.gastro.2025.06.003) evaluated safety outcomes across randomized trials and realworld studies of GLP1 RAs

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We used version 2 of the Cochrane risk-of-bias tool (ROB 2) to assess the risk of bias, conducted frequentist random-effects network meta-analyses and evaluated confidence in effect estimates utilising the Confidence In Network Meta-Analysis (CINeMA) framework

But every single ADR report can contribute to: Better patient safety Stronger drug safety databases Early signal detection Safer prescribing practices Improved public health decisions

Finally, we presented our insights on clinical concerns such as appropriate trial endpoints, management of comorbidities, and future developments