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Multiple case reports have noted marked improvements in AN in patients with and without obesity with the addition of metformin to their existing treatment regimens in doses ranging from 500 mg to 1700 mg daily

doi: 10.1016/j.phrs.2019.104615 [DOI] [PubMed] [Google Scholar] 146
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But its not just midlife women

The tirzepatide clinical data consistently shows superior results in this range

Colocalization analyses have pinpointed genetically correlated loci harboring putatively shared causal variants for both MDD and T2DM [57]
