semaglutide small molecule Antidiabetic drug molecular structure, illustration - Stock Image - C059/2722 GLP-1 Peptide VS Small Molecule!?!?
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While such compounds have been described, none have yet been considered credible pharmacological candidates (253, 254) due to a combination of factors, including insufficient potency, lack of specificity of binding to the GLP-1R and suboptimal half-life
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J Clin Pharmacol 1999;39:327-48
