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Table 3 Results of a 52-week Monotherapy Trial in Adults with Type 2 Diabetes Mellitus a Figure 3 Mean HbA 1c for Adult Patients with Type 2 Diabetes Mellitus who Completed the 52-week Trial and for the Last Observation Carried Forward (LOCF, intent-to-treat) data at Week 52 (Monotherapy) Combination Therapy Add-on to Metformin In this 26-week trial, 1,091 adult patients with type 2 diabetes mellitus were randomized to liraglutide injection 0.6 mg, liraglutide injection 1.2 mg, liraglutide injection 1.8 mg, placebo, or glimepiride 4 mg (one-half of the maximal approved dose in the United States), all as add-on to metformin

Then there was the knee osteoarthritis basket, which saw a roughly 70% decrease in osteoarthritis pain

Most of these patients had type 2 diabetes (90.5%) and obesity (75.2%)

Because MAO inhibitors target not only serotonin but also other monoamines like catecholamine hormones [230], one should be cautious to apply them to treat metabolic disorders

GLP-1RA exenatide administered once a week decreased heavy drinking days and total alcohol consumption, but only for a subset of participants with body mass index (BMI) over 30 19,20