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Description
As evidence continues to build on the benefits of GLP-1s across kidney, cardiovascular, liver, and metabolic disease, these drugs can increasingly be viewed as a therapy with multi-system value in patients with T2D or obesity

Weight: Berberine trials show average reductions of 2 to 5 pounds over 12 weeks
The ability for small biotech companies to move quickly, and their ability to take on risks, can sometimes give them an advantage over the deep pockets of big pharmaceutical companies

In the NTS, neurons expressing GLP-1 also express the leptin receptor [351,353]

Nat Commun 2019;10:2889
therefore, obesity is now considered to be a disease requiring treatment, rather than merely a cosmetic problem
