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There are currently no robust studies showing that smaller doses deliver the same cardiovascular or metabolic advantages, or even that they work consistently at all
GLP-1 Receptor agonist was proved by the Action Control Cardiovascular Risk in Diabetes trial (ACCORD) 75% decrease death rate in patients under Exentide treatment
There are various hypothesized mechanisms by which obesity may lead to insulin resistance and diabetes
doi: 10.1038/nature05401
It depends on the medications
