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Lets look at the actual numbers from the SURPASS clinical trial program the largest trials ever done on a diabetes drug: To put this in perspective most diabetes drugs reduce HbA1c by 0.51%

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10.1200/jco.2008.17.9291 83 ParkB.BakbakE.TeohH.KrishnarajA.DennisF.QuanA.et al (2024)

The practical answer is that these products may not compete in exactly the same way

From 2023 to 2025, MedStar Health served as a research site for the ATTAIN-1 trial, a phase III double-blind, placebo-controlled study of the safety and efficacy of the GLP-1 receptor agonist drug orforglipron

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