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Over the last decade, an increased number of glucose-lowering drugs have become available to treat type 2 diabetes, allowing for more individualized management of the disease

In particular, officials have called out versions that may contain ingredients that are similar to the active ingredient semaglutide but chemically different because they are in salt form

This creates a 5mg/mL concentration where a 1mg starting dose requires 20 units (easy to read on any syringe) and a 2mg dose requires 40 units (clean, precise marking)

Agnihothri RV, Courville AB, Linderman JD, et al

It should document your BMI (30+, or 27+ with a comorbidity), failed alternative treatments, and cardiovascular or metabolic risk, citing SURMOUNT-1 (20.9% average weight loss at 72 weeks) and SELECT (20% reduction in major cardiovascular events)

That third pathway is what separates retatrutide from everything else in the weight loss pipeline