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Tirzepatide for maintenance of bodyweight reduction in people with obesity in the USA (SURMOUNT-MAINTAIN)

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From triple agonists like Retatrutide to dual combinations and oral GLP-1 options, the pipeline reflects a strong shift toward: Higher efficacy in weight reduction Improved tolerability Flexible routes of administration (oral & injectable) Better management of comorbidities Promising outcomes across clinical trials show significant weight loss potential, with several molecules already in Phase 3 and nearing regulatory milestones

doi: 10.1016/j.diabres.2019.05.001 51 PerkovicV.De ZeeuwD.MahaffeyK

Full doses of these medications can cause gastrointestinal issues, such as nausea, vomiting, and diarrhea
