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Older participants occasionally took longer to reach full appetite suppression, but their 12-week weight loss percentages were comparable to younger participants

In conclusion, the degree to which GLP-1RAs cross the BBB is determined by a complex interplay of molecular and physicochemical factors

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Animal studies have demonstrated high concentrations of BBR in the liver, kidneys, lungs, heart, pancreas, brain, and skeletal muscles, often surpassing its plasma levels within 4 h post-administration [18,19]

Treatment plans may require slow increases or reductions over time

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